Excedrin Extra Strength Headache Relief Caplets are clinically proven pain relievers that act fast to alleviate various types of pain. Available in convenient caplet form, this non-prescription extra strength headache medicine works as hard as you do, combining aspirin and acetaminophen with caffeine. These active ingredients create a powerful formula with two pain fighters and a booster to offer temporary relief of aches and pains caused by headaches, colds, premenstrual and menstrual cramps, toothaches, muscular aches and arthritis. For some, relief with this Excedrin extra strength headache pain reliever can start in 15 minutes.