Nature Made Mood Plus SAM-e Complete 200 mg Tablets Enhances mood by promoting a healthy balance of neurotransmitters, dopamine and serotonin. Helps to reduce joint pain by helping to repair and maintain joint cartilage. Helps support detoxification and overall healthy liver functions. Is a safe, non-toxic and efficacious product to support health. Please Read Item Label and Packaging for Recent Product Information. Start with 2 tablets per day. The best time to take SAME-e is on an empty stomach at least 30 minutes before a meal. Clinical studies indicate that benefits are most likely evident after 7-14 days of supplementation. If benefits are not achieved with two weeks, may require a higher level of supplementation. To determine the proper level of supplementation that works for, gradually increase the number of tablets (maximum 1600 mg/day) until benefits are achieved. People with bipolar (manic) depression should not take this or any other product containing SAM-e except under a doctors supervision. If are pregnant or nursing, or taking antidepressant medications, consult your doctor before using this product.