Preparation H Soothing Relief Cleansing & Cooling Wipes keep you clean,. comfortable and irritation-free. These aloe and witch hazel wipes go beyond. cleaning to soothe discomfort. These anal and vaginal wipes have a formula to. calm burning and soothe itching on contact. Septic safe and biodegradable,. Soothing Relief Cleansing & Cooling Wipes are flushable medicated wipes that. are convenient and easy to use. Soothing Relief Cleansing & Cooling wipes are. soap free, fragrance free and paraben free. Use these butt itch relief wipes. to cleanse by wiping, patting or blotting up to six times a day. You can also. use these wipes before applying a topical anal itching treatment such as. Preparation H Soothing Relief Anti Itch Cream. Use as directed.