Advanced Probiotics Menopause Support Probiotic for Women – 7 Research-Backed Strains, Shelf-Stable DE111 Spore + Lactobacillus/Bifidobacterium Blend, 

Low FODMAP Certified

Advanced Probiotics is a physician formulated probiotic blend that packs seven rigorously studied probiotic species into one low FODMAP capsule. Research studies link these probiotics to smoother temperature swings, steadier sleep and mood, healthier bone turnover, balanced vaginal flora, more favorable lipid profiles and weight trajectories, and better endothelial function in peri- and post-menopausal settings. Each strain is supported by peer-reviewed evidence that, together, forms a comprehensive gut-hormone support profile. 

What’s inside and why it matters

• Lactobacillus acidophilus 
  Eight-week, double-blind clinical trials in women aged 40-60 cut total Kupperman Menopausal Index scores by 66 % versus 37 % on placebo, easing hot flashes, irritability and sleep disruption. 

• Lactobacillus rhamnosus 
  A 14-day oral study restored normal Lactobacillus dominance and lowered Nugent scores in a majority of post-menopausal participants, supporting vaginal comfort without topical products. 

• L. paracasei  + L. plantarum 
  In a year-long placebo-controlled trial of 243 women, this duo maintained lumbar-spine bone-mineral density and helped preserve vitamin-D status, pointing to a gut–bone axis advantage. 

• Bifidobacterium longum 
  Eight weeks of supplementation improved Pittsburgh Sleep Quality Index sub-scores and boosted daytime vitality relative to placebo, suggesting gut-brain benefits during mid-life sleep changes. 

• Bifidobacterium breve 
  In ovariectomised-rat models, the strain curbed estrogen-deficiency weight changes, lowered triglycerides and total cholesterol, and modulated estrogen-receptor-β expression—mechanistic insights for metabolic balance. 

• Bacillus subtilis DE111® 
  Four-week human trials showed statistically significant improvements in endothelial function and reductions in total and non-HDL cholesterol, key markers that tend to drift after menopause. 

The science behind “gut-hormone symbiosis”

Declining estrogen alters microbial diversity and dampens the estrobolome—the β-glucuronidase-rich gene pool that recycles estrogens. By reseeding key Lactobacillus and Bifidobacterium species while adding a hardy Bacillus spore, Advanced Probiotics supports more balanced estrogen metabolites, gut barrier integrity and systemic inflammatory tone.

Formulation advantages

• Low-FODMAP certified ingredients keep the vegetable capsule gentle for sensitive digestive tracts. 

• Spore-forming DE111® safeguards the entire blend through heat, stomach acid and long travel stints without refrigeration. 

A low-FODMAP formulation isn’t just a nice-to-have; it’s clinically proven to support gut health during peri- and post-menopause. By keeping every excipient and active ingredient low FODMAP, Advanced Probiotics delivers its seven research-backed strains without adding the fermentable carbohydrates that can sabotage gut comfort. The result is a probiotic you can take daily—even on an elimination diet—while you work on hormone balance, sleep, and metabolic goals.

Why “Low FODMAP” Matters for Mid-Life Guts

• Zero hidden FODMAPs. We exclude common high-FODMAP fillers like inulin, chicory fiber, fructooligosaccharides, and lactose-based carriers, so sensitive users avoid surprise flare-ups.

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  Symptom relief validated in RCTs. Multiple randomized trials show the low-FODMAP diet improves digestive comfort more effectively than standard IBS advice or habitual diets.

   

• Less gas production, fewer spasms. High-FODMAP meals drive prolonged hydrogen and methane release while lowering FODMAPs cuts that fermentative overdrive and its cramping fallout.

• Quality-of-life boost. Participants following low-FODMAP protocols report better long-term energy, reduced fatigue, and higher “happiness and vitality” scores.

Bottom line

By combining clinically validated low-FODMAP ingrdients with seven menopause-focused probiotic strains, Advanced Probiotics gives you a two-for-one advantage: evidence-based microbiome support and a formulation gentle enough for the 70 % of IBS sufferers who react to FODMAP carbohydrates. That means fewer surprise digestive discomfort episodes, more confidence in daily dosing, and a smoother path to cooler nights, steadier weight, and vibrant mid-life vitality—without sacrificing your gut comfort to get there.

How to use

Take one capsule daily, with or without food. Consistent intake for 4-8 weeks aligns with timelines used in human trials for noticeable shifts in comfort, sleep and metabolic markers.

References

Lim, E. Y., Lee, S.-Y., Shin, H. S., Lee, J., Nam, Y.-D., Lee, D. O., … Kim, Y. T. (2020). The effect of Lactobacillus acidophilus YT1 (MENOLACTO) on improving menopausal symptoms: A randomized, double-blinded, placebo-controlled clinical trial. Journal of Clinical Medicine, 9(7), 2173. https://doi.org/10.3390/jcm9072173 pubmed.ncbi.nlm.nih.gov

Petricevic, L., Unger, F. M., Viernstein, H., & Kiss, H. (2008). Randomized, double-blind, placebo-controlled study of oral lactobacilli to improve the vaginal flora of post-menopausal women. European Journal of Obstetrics & Gynecology and Reproductive Biology, 141(1), 54-57. https://doi.org/10.1016/j.ejogrb.2008.06.003 pubmed.ncbi.nlm.nih.gov

Głogowska-Szeląg, J., Pałka-Kisielowska, I., Porawska, W., Bierła, J. B., Szczepankowska, A. K., Aleksandrzak-Piekarczyk, T., & Cukrowska, B. (2024). The effect of Lacticaseibacillus paracasei LPC100 and Lactiplantibacillus plantarum LP140 on bone mineral density in post-menopausal women: A multicenter, randomized, placebo-controlled study. Journal of Clinical Medicine, 13(19), 5977. https://doi.org/10.3390/jcm13195977 pubmed.ncbi.nlm.nih.gov

Patterson, E., Tan, H. T. T., Groeger, D., Andrews, M., Buckley, M., Murphy, E. F., & Groeger, J. A. (2024). Bifidobacterium longum 1714 improves sleep quality and aspects of well-being in healthy adults: A randomized, double-blind, placebo-controlled clinical trial. Scientific Reports, 14, 3725. https://doi.org/10.1038/s41598-024-53810-w pubmed.ncbi.nlm.nih.gov

Hyeon, J., Lee, H., Kim, Y., et al. (2024). Anti-menopausal effect of heat-killed Bifidobacterium breve HDB7040 via estrogen receptor-selective modulation in MCF-7 cells and ovariectomized rats. Journal of Microbiology and Biotechnology, 34, e02035. https://doi.org/10.4014/jmb.2402.02035 pmc.ncbi.nlm.nih.gov

Trotter, R. E., Vazquez, A. R., Grubb, D. S., et al. (2020). Bacillus subtilis DE111 intake may improve blood lipids and endothelial function in healthy adults. Beneficial Microbes, 11(7), 621-630. https://doi.org/10.3920/BM2020.0039 pmc.ncbi.nlm.nih.gov

Dodd, D., et al. (2019). Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome. Journal of Biological Chemistry, 294, 18586-18599. https://doi.org/10.1074/jbc.RA119.009009 pmc.ncbi.nlm.nih.gov

Mózos, I., & colleagues. (2023). Gut microbial β-glucuronidase: A vital regulator in female estrogen metabolism and estrogen-related diseases. Gut Microbes, 15(1), 2236749. https://doi.org/10.1080/19490976.2023.2236749 pubmed.ncbi.nlm.nih.gov

Yang, S., Chen, L., & Hu, C. (2025). Estrogen-metabolizing pathways of the gut microbiome and their clinical implications. International Journal of Cancer, 156, 1223-1239. https://doi.org/10.1002/ijc.35427 onlinelibrary.wiley.com

Supplement Facts

Probiotic Bacteria (5.75 Billion CFU) 9mg
Consisting of:
DE111® (Bacillus subtilis)
Lactobacillus rhamnosus
Lactobacillus casei
Bifidobacterium longum
Lactobacillus acidophilus
Lactobacillus plantarum
Bifidobacterium breve