S-adenosyl-L-methionine (SAMe) is a natural occurring substance essential in the production of the mood elevating neurotransmitter serotonin. Why Tablets Make a Better SAMe Product To be effective in the body, these ingredients must reach the intestines intact. Capsules dissolve in the stomach, rendering the ingredients of little value to the patient. Enteric coated tablets dissolve after the stomach, bringing ingredients to the intestines for maximum usefulness. We use the Disulphate Tosylate form of SAMe, known to be among the most stable forms available.