Take control of your frequent heartburn with Prilosec OTC. This 14-day course of treatment is specifically designed for individuals who experience heartburn two or more days a week. Each 20mg tablet works by blocking the acid production at its source, providing a full 24 hours of relief with just one pill a day. While antacids provide immediate but temporary relief, Prilosec OTC is a "delayed-release" formula that may take 1 to 4 days for full effect, but it offers a long-term solution to prevent symptoms before they start. It is the #1 doctor-recommended OTC frequent heartburn medicine for over 15 years.